Toward a Vaccine Against Hepatitis C Virus

A vaccine protecting against chronic infection with hepatitis C virus (HCV) is urgently needed to address the ongoing public health crisis caused by this insidious pathogen — a major cause of liver cirrhosis and cancer. Efforts toward development of vaccines were initiated after the discovery of HCV in 1989, but to date, no vaccine has been licensed. An increased understanding of HCV protective immunity and HCV envelope glycoprotein structure and function is paving the way toward rational vaccine design and evaluation.

Access the full perspective, published in Science, here.